Br J Pharmacol. 1988 Jul;11(7):505-6. doi: 10.1002/clc.4960110714. Nifedipine is 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester, C 17 H 18 N 2 O 6, and has the structural formula: Nifedipine is a yellow crystalline substance, practically insoluble in water but soluble in ethanol. whole fruit, juice and rind), can significantly increase serum levels of nifedipine and may cause toxicity. 1986 May;38(5):399-400. doi: 10.1111/j.2042-7158.1986.tb04598.x. Epub 2012 May 15. Calcium-channel blocker; inhibits transmembrane influx of extracellular calcium ions across myocardial and vascular smooth muscle cell membranes without changing serum calcium concentrations; this results in inhibition of cardiac and vascular smooth muscle contraction, thereby dilating main coronary and systemic arteries [9] This was found to be dangerous, and has been abandoned. Interestingly, however, many of the listed effects (see Table 1) can also be caused by adenosine. The drug may be quantified in blood or plasma to confirm a diagnosis of poisoning, or to assist in a medicolegal investigation following death. Mol Pharmacol. SmPC; Patient Leaflet; Adanif XL 30mg Tablets nifedipine ADVANZ Pharma. Nifedipine is a yellow crystalline substance, practically insoluble in water but soluble in ethanol. C. The mechanism by which nifedipine reduces arterial blood press… Generic name: Nifedipine. [12], Nifedipine has been used frequently as a tocolytic (agent that delays premature labor). Amlodipine mechanism of action Amlodipine besylate is a second generation calcium channel blocker with antihypertensive and antianginal properties. [25] This study was a meta-analysis, and demonstrated harm mainly in short-acting forms of nifedipine (that could cause large fluctuations in blood pressure) and at high doses of 80 mg a day and more. The increased peripheral vascular resistance, an underlying cause of hypertension, results from an increase in active tension in the vascular smooth muscle. [15], Nifedipine is also used in high-altitude medicine to treat high altitude pulmonary edema. The mechanism by which nifedipine reduces arterial blood pressure involves peripheral arterial vasodilatation and the resulting reduction in peripheral vascular resistance. J Pharmacol Exp Ther. [, Ramachandran SD, Vivares A, Klieber S, Hewitt NJ, Muenst B, Heinz S, Walles H, Braspenning J: Applicability of second-generation upcyte(R) human hepatocytes for use in CYP inhibition and induction studies. [16], Nifedipine is one of the main choices for the treatment of Prinzmetal angina due to its vasodilating effects on the coronary arteries. The mechanism by which nifedipine reduces arterial blood pressure involves peripheral arterial vasodilatation and, consequently, a reduction in peripheral vascular resistance. Lee et al., 2006, Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms., Pharmacology NIFEDIPINE SLC14A2 Interaction Score: … These problems are much less frequent in the sustained-release preparations of nifedipine. [10][11] An exception to the avoidance of this practice is in the use of nifedipine for the treatment of hypertension associated with autonomic dysreflexia in spinal cord injury. Xenobiotica. The risk or severity of congestive heart failure and hypotension can be increased when Nifedipine is combined with Acebutolol. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. Mechanism of Action. 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