Atherosclerosis 57(1):65-73, Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. J Lipid Res 32(4):559-68, Paigen B; Morrow A; Brandon C; Mitchell D; Holmes P. 1985. endstream Genetics of age-related hearing loss in mice. <>stream Taconic's B6 Provides Superior Performance. BALB/c is an albino, laboratory-bred strain of the house mouse from which a number of common substrains are derived. This C-to-T transition, the T variant of SNP rs46447118, found in C57BL/6J and C57BL/6JEiJ but not any of the other 18 inbred strains tested, is in nucleotide 50 in the stem of the T loop and impairs maturation, leading to accumulation of a 105 nucleotide pre-tRNA band with leader and trailer sequences instead of the usual 115 nucleotide pre-tRNA, and also diminishes aminoacylation of this isodecoder. %PDF-1.6 Our mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health. III. Macronutrient diet selection in thirteen mouse strains. <>>>/BBox[0 0 585 783]/Length 114>>stream Lab Anim Sci 44(6):551-60, Ulland TK; Jain N; Hornick EE; Elliott EI; Clay GM; Sadler JJ; Mills KA; Janowski AM; Volk AP; Wang K; Legge KL; Gakhar L; Bourdi M; Ferguson PJ; Wilson ME; Cassel SL; Sutterwala FS. Clinical Chemistry Reference Intervals for C57BL/6J, C57BL/6N, and C3HeB/FeJ Mice (Mus musculus). However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. 1�^���|7�PE$HG�cD�d�ҥ8C&���GӦmйM���u A{l��0�^aU[���"��֔���~%��6>��m <>stream The T variant of SNP rs48804829 at coding nucleotide 1352 codes for a leucine at codon 451 which yields a peptide with severely reduced activity. Genetic differences among C57BL/6 substrains. 27 0 obj 18 0 obj 17 0 obj Most inbred strains, including C57BL/6J, C3H/HeJ, and BALB/cJ, carry an influenza susceptible Mx1s1 allele which produces mRNA lacking exons 9, 10, and 11 of the Mx1r allele. Prior to placement, all C57BL/6J mice were screened by fecal PCR (Mouse Surveillance Plus PRIA … Mice Male B6.129S7-Rag1tm1Mom/J (B6.Rag1−/−) mice were directly imported from the Jackson Laboratory in 2009 and kept strictly in-bred in pathogen-free individually ventilated cage housing in our animal facility. When using B6 mice it is very important to reference the full nomenclature that indicates its provenance and vendor code (eg, C57BL/6NTac from Taconic and C57BL/6J from The Jackson Laboratory). False 5 SNP differences have been identified that distinguish C57BL/6J from C57BL/6ByJ and C57BL/6NJ. converted This strain is available from some international Charles River (CR) breeding facilities in Japan and/or Europe. The variation in aortic lesions found among various inbred strains has led to the identification of the existence of eight genes affecting atherosclerosis, Ath1 to Ath8. x�S�*�*T0T0 B�����i������ yn) Watch Video. The differences between B6 substrains is more than just semantics; not only are they genetically unique, but these attributes also affect their suitability for use as specific research models. J Lipid Res 31(3):467-77, Kirk EA; Moe GL; Caldwell MT; Lernmark JA; Wilson DL; LeBoeuf RC. 2009. xmp.iid:c31c0f8a-1532-ed4d-a998-9ccad6f57fa8 A substantial proportion of these mice exhibit seizure activity. A G to A conversion within a cryptic splice site results in the preferential incorporation of a pseudo-exon, containing an in-frame stop codon as the second codon, into the transcript. 2000. endstream C57BL/6JOlaHsd Mice from Envigo (Harlan), Bicester, UK Deletion of Snca – no visible phenotype, but… Neurological Differences 22 Specht CG and Schoepfer R. 2001. This model is perinatal lethal in homozygouse animals which die shortly after birth, presumably from breathing difficulties due … J Immunol 129(4):1530-3, Smith BK; Andrews PK; West DB. 1998. 1994. <>stream 13 14 • Eyes are open • Pups begin to nibble solid food • Pups increase • Pups solid food intake in weight increase and size, eating more solid food . The mutation lies within a C-terminal cytoplasmic domain homologous with the TNFR 1-death domain and with an SH3 binding protein. Formerly: B6.Cg-Tg(Prnp-SNCA*A53T)23Mkle/J Genetic Background: Established as C3H/HeJ x C57BL6/J hybrids, then maintained by backcrossing to C57Bl6/J. C57BL/6JOlaHsd Mice from Envigo (Harlan), Bicester, UK Deletion of Snca – no visible phenotype, but… Neurological Differences 22 Specht CG and Schoepfer R. 2001. x�+� � | Further analysis has shown this is caused by a G to A transition at coding nucleotide position 753 of Cdh23 (SNP rs257098870). Terms are granted by individual review and stated on the customer invoice(s) and account statement. Variation in type 2 diabetes--related traits in mouse strains susceptible to diet-induced obesity. Am J Respir Cell Mol Biol 23(4):537-45, Freeman HC; Hugill A; Dear NT; Ashcroft FM; Cox RD. Diabetes 65(1):25-33, Ishida BY; Blanche PJ; Nichols AV; Yashar M; Paigen B. The B6.NODC11b and B6.NODC1tb subcongenic mouse strains were derived for this study from backcrossing the B6.NODC11 and B6.NODC1 mice in the University of Florida Department of Pathology SPF Mouse colony, which were originally derived by Yui and Wakeland,1 with C57BL/6J mice from Jackson Laboratory for three to five generations then intercrossing the offspring for three generations … Allergen-induced airway disease is mouse strain dependent. Genetic polymorphisms among C57BL/6 mouse inbred strains. endobj <>>>/BBox[0 0 585 783]/Length 114>>stream endstream JAX® Mice strains are only made available to researchers after meeting our standards. The Mx genes determine resistance to the lethal effects of various myxoviruses including neurotropic avian influenza A virus injected intracerebrally, pneumotropic strains injected intranasally, and a hepatotropic strain injected intraperitoneally (J:5645, J:13136). 2005. Querying the sequences of the Sanger Mouse Genomes Project reveals that the short allele with its 6 bp deletion exists in C57BL/6J, C57BL/10J, C57BL/6NJ, C58/J, BALB/cJ, C3H/HeH, 129S5/SvEvBrd, NZW/LacZ, and SEA/GnJ, but the long allele lacking the deletion exists in 129S1/SvImJ, A/J, AKR/J, BTBR T, This allele contains a 6 bp microdeletion causing the loss of two amino acids and truncating the protein to 111 amino acids instead of 113 amino acids. endstream Susceptibility of inbred and F1 hybrid strains to noise-induced hearing loss. <>stream These mice are on a congenic C57/BL genetic background. 2016. x�%�A�@�}O�(��'.�r�^���� x�S�*�*T0T0 B�����i������ yS& The Mx1r allele occurs only in strains A2G, SL/NiA, and T9, the latter being a strain derived from an influenza-resistant wild stock, and CAST/Ei, derived from Mus musculus castaneus. Mice. <>stream NOD, B6, and BALB/c mice were purchased from Jackson Laboratory and then bred and maintained under specific pathogen-free conditions in the animal facility of the Centro de Investigaciones en Bioquímica Clínica e Inmunología, Universidad Nacional de Cordoba, Argentina. Reversal of diet-induced obesity and diabetes in C57BL/6J mice. Since C57BL/6JEi separated from C57BL/6J in 1976, the Nnt deletion arose sometime between 1976 and 1984. Availability: Available through The Jackson Laboratory… Genetic loci determining bone density in mice with diet-induced atherosclerosis. Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene. x�+� � | It also maintains an integrated mouse information resource. Festing Inbred Strain Characteristics: C57BL, National Center for Biotechnology Information / SNP Data, Additional Breeding and Husbandry Support. Enter your email if you are happy for us to connect and reachout to you with more questions. Watch this video to learn how The Jackson Laboratory's unique Genetic Stability Program effectively limits cumulative genetic drift. Wound healing and cross circulation is established in two to three days. Also known as B6 ob, these animals are homozygous for the obese spontaneous mutation, Lep ob (often referred to as ob or ob/ob), show obesity, hyperphagia, transient hyperglycemia, glucose intolerance, and elevated plasma insulin.Ob/ob mice are also hypometabolic, hypothermic, and often subfertile. x�+� � | … C57BL/6J is the most widely used inbred strain. C57BL/6-Elite (SOPF) Mouse Details. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research. This allele confers increased forebrain weight compared to DBA/2J. To Hall in 1948 from The Jackson Laboratory. Roscoe B. Jackson was a one-time head of the Hudson Motor Company who helped provide the funds for the first laboratory building at the property and the first five years of operation.) Nat Med 14(2):194-8, Ishimura R; Nagy G; Dotu I; Zhou H; Yang XL; Schimmel P; Senju S; Nishimura Y; Chuang JH; Ackerman SL. endstream 2001. They are also susceptible to diet-induced obesity, type 2 diabetes, and atherosclerosis. 1996. Hybrid mice, such as B6C3, a cross between C57BL/6J females (B6) and C3H/HeJ males (C3), is gaining popularity. Pathophysiological mechanisms underlying phenotypic differences in pulmonary radioresponse. In addi-tion, detailed behavioral observations were made of the males. This strain is available from some international Charles River (CR) breeding facilities in Japan and/or Europe. Science 342(6165):1508-12, McKhann GM 2nd; Wenzel HJ; Robbins CA; Sosunov AA; Schwartzkroin PA. 2003. One of the most used inbred mouse models, the C57BL/6 is used in nearly every research application, and it's commonly used as the genetic background for transgenic mouse models. 22 0 obj uuid:e46a0396-ed28-431b-b0a8-ff16e0f3881c The Jackson Laboratory’s Mission 4 Performing Research Investigating genetics and biology of human disease Providing Resources JAX® Mice Clinical & Research Services, bioinformatics data, technical publications and more… Genetic heterogeneity of angiogenesis in mice. More than 11,000 strains of mice are available from The Jackson Laboratory. It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. endobj Thank you for sharing your feedback! 2003. For more information, see the Worldwide Distributor List for JAX® Mice. 1998. Behav Brain Res 176(1):4-20, Nguyen PV; Duffy SN; Young JZ. C57BL/6N mutation in Cytoplasmic FMRP interacting protein 2 regulates cocaine response. 2003. 4 0 obj 1991. This strain lacks any overt phenotype related to the transgene. Colonies of Laboratory Mice A Jackson Laboratory Resource Manual Th is manual describes breeding strategies and techniques for maintaining colonies of laboratory mice. Genetic variability in adult bone density among inbred strains of mice. Proc Natl Acad Sci U S A 91(12):5667-71, Welkos SL; Keener TJ; Gibbs PH. endobj Although this strain is refractory to many tumors, it is a permissive background for maximal expression of most mutations. The CBA/J, CE/J, I/LnJ, and PERA/Ei strains, also susceptible to the virus, have another form of the Mx1s2 allele in which there is a nonsense mutation (J:9452). A sequence variant is identified in C57BL/6J (T) as compared to C57BL/6N (C) at position 3,222,537 (GRCm38). B6.Rag1-/- mice displayed nearly identical blood pressure increases monitored via radiotelemetry and hypertensive end-organ damage in response to different doses of Ang II and different levels of salt intake (0.02%, 0.3%, and 3% NaCl diet). How easy was it to find what you were looking for? One of the unique advantages to working with mice, rather than other experimental organisms, is the availability of standard strains such as C57BL/6 (abbreviated B6), BALB/c, and many others that are used in thousands of laboratories around the world each year. It is near a spice acceptor site and causes a substantial decrease in expression at the mRNA and protein levels in homozygous brain, with additional decreases in Gabra1, Gabra3, and Gabra5 transcripts in striatum This allele can be phenoytpically reversed entirely by the correction of this intronic point deletion (see, Black BL; Croom J; Eisen EJ; Petro AE; Edwards CL; Surwit RS. The protein is located in the nucleus (J:7703) and produces its antiviral effect by preventing synthesis of viral mRNA in the nucleus (J:7992). This widely used … Although some interferon-induced genes respond directly to virus invasion as well as indirectly through induction by virus-induced interferon, this primary response is very weak for the MX-1 protein in response to either influenza or Newcastle disease viruses (J:1892). This change would prevent the 43 amino acid extension of mRNA translation predicted for the DBA/2J allele and account for the smaller size of the peptide produced by this allele (95 kDa vs 104 kDa for the DBA/2J allele). Twelve SNPs were found informative to discriminate among the mouse strains considered. Parabiosis requires the surgical joining of two mice by skin-to-skin anastomosis from the shoulder to the pelvic girdle. Labeling: Article Title: IL … This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset after 10 months of age. Genes Dev 7(3):454-67, Moy SS; Nadler JJ; Young NB; Perez A; Holloway LP; Barbaro RP; Barbaro JR; Wilson LM; Threadgill DW; Lauder JM; Magnuson TR; Crawley JN. Both C57BL/6ByJ and C57BL/6NJ type as follows: 08-015199792-M (rs3709624) is C; 11-004367508-M (rs3659787) is A; 13-041017317-M (rs3722313) is C; 15-057561875-M (rs3702158) is G; 19-049914266-M (rs3724876) is T. C57BL/6J types as follows: 08-015199792-M (rs3709624) is T; 11-004367508-M (rs3659787) is G; 13-041017317-M (rs3722313) is T; 15-057561875-M (rs3702158) is A; 19-049914266-M (rs3724876) is G (Petkov and Wiles, 2004.) This hypomorphic allele changes splice donor site G-GT to A-GT, causing frame skipping of exon 7. Genetics of responsiveness to high-fat and high- cholesterol diets in the mouse. .. All mice were backcrossed and maintained at C57BL/6 background and housed in the special pathogen-free facilities. The hybrid mice are heterozygous genetically and tend to serve as a background for some deleterious mutations. 12 . default B6.Cg- Kit W-44J Gpi1 a : A mouse strain with the genetic background of C57BL/6, but where the donor strain is mixed, the Kit allele originating from C3H/HeJ and the Gpi1 allele originating from CAST/Ei. To Charles River in 1974 from NIH. from application/x-indesign to application/pdf Control male C57Bl/6J mice were also obtained from the Jackson Laboratory via Charles River–the exclusive li- This model was created by microinjecting the human APP 695 gene containing the double mutation K670N, M671L into B6SJLF2 zygotes using a hamster prion protein cosmid vector. Comparison of allergic lung disease in three mouse strains after systemic or mucosal sensitization with ovalbumin antigen. 11 0 obj B6;129P2- Il2tm1Hor (original publication) 4-9 wks Progressive Yes B6.129P2-Il2tm1Hor/J pre & post wean loss, 10-25 weeks Progressive Yes C.129P2(B6)-Il2tm1Hor/J 3-5 wks None Yes Schorle H et al. 2020-02-18T09:32:19-08:00 2020-02-06T13:32:01+05:30 endobj 2000. Strain background had a significant effect on the onset and severity of ocular phenotypes in Lmx1b V265D/ + mutant mice. PMID: 11591219 C57BL/6J Genomic DNA from The Jackson Laboratory Wild-type Snca C57BL/6NCrl Mice from Charles River, Margate, UK Wild-type Snca In vitro analysis demonstrates that the resulting truncated protein, which lacks several conserved C-terminal motifs, has less than 1% enzyme activity when compared to control C3H/HeJ mice. Animals were maintained in a 16 h light-8 h dark cycle, at 20 ± 2 °C, with food and water ad libitum. 2014. Volume Pricing Program A transgenic construct containing a 2.34 kb rat albumin enhancer/promoter, nuclear localization sequence-modified Cre recombinase and a 2.1 kb fragment from the human growth hormone gene was injected into B6D2(F2) pronuclei. C57BL/6, often referred to as "C57 black 6", "C57" or "black 6", is a common inbred strain of laboratory mouse.. Nuclear localization is necessary for anti-influenza virus activity (J:1417), but mutations induced in Mx1 showed that nuclear position was not sufficient for the effect; mutations in several domains can cause its loss (J:11840). One of these, a C to T transition in exon 11 would change the arginine codon in the DBA/2J allele to an opal termination codon in the C57BL/6J allele. endstream Social contact was detected by an automated system when the distance between the centers of the two animals became less than *12 cm. Th ey are safe, reliable, economical, effi cient, and ensure that The approximate age of mouse pups can be determined by their physical attributes during the irst two weeks of life. Synthetic low and high fat diets for the study of atherosclerosis in the mouse. The JAX Synteny Browser for mouse-human comparative genomics. xmp.did:C6AD69875588E0119B65E91AE40D8D8E The wild-type C variant, coding for proline, is found in 129P2/OlaHsd, 129S1/SvImJ, 129S5SvEvBrd, A/J, BALB/c, CAST/EiJ ,NZW, LP/J, NOD/ShiLtJ, PWK/PhJ, WSB/EiJ, Mus caroli, M. spretus, M. musculus, and M. poschiavinus. Dietary obesity in nine inbred mouse strains. Genome Res 14(9):1806-11, Roberts JE; Watters JW; Ballard JD; Dietrich WF. endstream x�%�A�@�}O�(��'.�r�^���� C57BL/6J was the DNA source for the international collaboration that generated the first high quality draft sequence of the mouse genome. 2019 Dec;30(11-12):353-361. <>stream C57BL/6J mice are used in a wide variety of research areas including cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and sensorineural research. The following phenotype relates to a compound genotype created using this strain. Low levels of melatonin production in C57BL/6J mice have been correlated with a point mutation in the gene encoding arylalkylamine N-acetyltransferase. <>>>/BBox[0 0 585 783]/Length 114>>stream x�%�A�@�}O�(��'.�r�^���� Therefore, we cannot guarantee a strain's phenotype will meet all expectations. 2004. <>stream endstream They are the most widely used and best-selling mouse strain, due to the availability of congenic strains, easy breeding, and robustness. Although this strain is refractory to many tumors, it is a permissive background for maximal expression of most mutations. This is a dominant trait. the Jackson Laboratory were using parabio-sis to characterize anemia mutant mice and were pleased to instruct me in this technique. endobj Comparison of acute endotoxin-induced lesions in A/J and C57BL/6J mice. This strain is the most well characterized, the first to have its’ entire genome sequenced, and is the genetic background strai . Exp Hematol 28(4):442-50, Depis F; Kwon HK; Mathis D; Benoist C. 2016. 1986. Diabetologia 48(4):675-86, Waterston RH; Lindblad-Toh K; Birney E; Rogers J; Abril JF; Agarwal P; Agarwala R; Ainscough R; Alexandersson M; An P; Antonarakis SE; Attwood J; Baertsch R; Bailey J; Barlow K; Beck S; Berry E; Birren B; Bloom T; Bork P; Botcherby M; Bray N; Brent MR; Brown DG; Brown SD; Bult C; Burton J; Butler J; Campbell RD; Carninci P; Cawley S; Chiaromonte F; Chinwalla AT; Church DM; Clamp M; Clee C; Collins FS; Cook LL; Copley RR; Coulson A; Couronne O; Cuff J; Curwen V; Cutts T; Daly M; David R; Davies J; Delehaun. endobj Effects of atherogenic diet consumption on lipoproteins in mouse strains C57BL/6 and C3H. The Jackson Laboratory, founded by Clarence Cook Little, who produced the inbred mouse strain C57BL, among others, is the most cited experimental murine animal supplier. This variant is found in AKR/J, C3H/HeJ, C57BL/6, C57BL/10, CBA/J, DBA/1, DBA/2, FVB/NJ, and NZO/HILtJ. Mice belong to the Euarchontoglires clade, which includes humans. endobj Immunogenetics 61(3):199-207, Zurita E; Chagoyen M; Cantero M; Alonso R; Gonzalez-Neira A; Lopez-Jimenez A; Lopez-Moreno JA; Landel CP; Benitez J; Pazos F; Montoliu L. 2011. The laboratory mouse or lab mouse is a small mammal of the order Rodentia which is bred and used for scientific research.Laboratory mice are usually of the species Mus musculus.They are the most commonly used mammalian research model and are used for research in genetics, psychology, medicine and other scientific disciplines. Nat Commun 7:13180, Vrieling H; Duhl DM; Millar SE; Miller KA; Barsh GS. If you are interested in these mice or willing to disclose your mouse … x�+� � | Quantities: Volume pricing is automatically applied when a minimum quantity per strain for a shipment is reached Transgenic Res 20(3):481-9. 2000. Strain of origin - this allele was found in C57BL/6, C58/J, C57BR, MA/My strains. The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration. BALB/c is an albino, laboratory-bred strain of the house mouse from which a number of common substrains are derived. Examples of the developmental stages of albino, agouti, and black pups are shown. J Lipid Res 36(7):1522-32, Kumar V; Kim K; Joseph C; Kourrich S; Yoo SH; Huang HC; Vitaterna MH; de Villena FP; Churchill G; Bonci A; Takahashi JS. 12 0 obj 2002. 5 0 obj Holth JK et al used Jackson Laboratory B6C3F1/J mice (#100010) and B6C3 tau P301S mice (# 008169) to study mouse brain interstitial fluid tau level during … Because of the n-Tr20m1J point mutation, which is also present in C57BL/6JEiJ but not C57BL/6NJ or C57BL/6ByJ, extracts from the cerebellum of C57BL/6J mice have increased ribosomal pausing at AGA codons compared with that of other inbred strains (Ishimura et al., 2014). endobj Watch this video to learn the importance of the C57BL/6 inbred mouse (B6), the most commonly used research strain. Study-ready aged C57BL/6J males and females between 25 - 90 weeks of age available for order. C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss. Variation in susceptibility to atherosclerosis among inbred strains of mice. endobj The same cross gave rise to the C57L and C57BR strains. Adobe InDesign CC 2015 (Windows) Behav Brain Res 108(1):39-45, Schlagel CJ; Ahmed A. Little in 1921, from a mating of Miss Abby Lathrop’s stock that also gave rise to strains C57BR and C57L. xmp.id:3fc93184-1b25-7b4b-bee8-5451dbe7f73b endstream 2019 Jun 5;9(6):1795-1805. It is commonly used as a general purpose strain and background strain for the generation of congenics carrying both spontaneous and induced mutations. Arteriosclerosis 10(2):316-23, Parekh PI; Petro AE; Tiller JM; Feinglos MN; Surwit RS. (8). B6 mice were mated to CAST, and the F1 hybrids were backcrossed to B6. Neuroscience 122(2):551-61, Mekada K; Abe K; Murakami A; Nakamura S; Nakata H; Moriwaki K; Obata Y; Yoshiki A. 1991. RT-PCR demonstrated cDNA corresponding to exons 7-11 was absent. Differential maintenance and frequency-dependent tuning of LTP at hippocampal synapses of specific strains of inbred mice. Th ese techniques have been developed and used by Th e Jackson Laboratory for over 75 years. Little in 1921, from a mating of Miss Abby Lathrop’s stock that also gave rise to strains C57BR and C57L. PCR sequencing of cDNA revealed ten nucleotide differences between the coding sequences of the DBA/2J and C57BL/6J receptors. Resistance is specific for the orthomyxoviruses (J:6265). Article Title: Role of IRAK-M in Alcohol Induced Liver Injury Article Snippet: ..We used C57B/L6 mice from the Jackson Laboratory as controls, and these mice were used to backcross the IRAK-M−/− mice. Other characteristics include: 1) a high susceptibility to diet-induced obesity, type 2 diabetes, and atherosclerosis; 2) a high incidence of microphthalmia and other associated eye abnormalities; 3) resistance to audiogenic seizures; 4) low bone density; 5) hereditary hydrocephalus (early reports indicate 1 - 4 %); 6) portosystemic shunts (~5%); 7) hairloss associated with overgrooming; 8) a preference for alcohol and morphine; 9) late-onset hearing loss; 10) increased incidence of hydrocephalus and malocclusion and 11) spontaneous calcaneal luxation in 1% of aged males beginning at 6-8 months of age, resulting in ankylosing enthesopathy of that tarsal joint. ; Kozak LP use as models of human disease strains classified with ahl that do not produce the (... Roderick Th ; Sundberg JP and C57BL/6NJ is identified in strain LG/J of... Detected by an automated system when the distance between the mdfw ( modifier of deaf waddler locus... Mice have twice the muscle mass of normal mice that possess the gene for producing myostatin and. Were looking for homologous with the helminth Schistosoma mansoni results in hepatointestinal granulomatous inflammation mediated by CD4 T cells against! Reference Intervals for C57BL/6J, C58/J, C57BR, MA/My strains Lathrop ’ s stock also... At the University of Pennsylvania Medical Center MA/My strains seizures, have a low to. The granted terms phenotype of each strain may not be fully characterized and/or captured in the gene encoding N-acetyltransferase. Of Laboratory mice a Jackson Laboratory at F32 J Immunol 129 ( 4 ):1530-3, Smith RS Roderick! Children ’ s stock that also gave rise to strains C57BR and C57L ):795-800, West ;., C3H/HeJ, C57BL/6, C58/J, C57BR, MA/My strains,,! T ; Yuan J ; Zhang a ; Udagawa T ; Yuan J ; Paigen B FMRP interacting 2. Res 32 ( 4 ):205-15, Fontaine DA ; Davis DB: 89/100, based 47... Have twice the muscle mass of normal mice that possess the gene encoding arylalkylamine N-acetyltransferase YW! Study of atherosclerosis in the mouse genome Reference strain ):1087-92, J. And C3HeB/FeJ mice ( Mus musculus ) placement, all C57BL/6J mice breed well, are long-lived, black. B ; Morrow a ; Udagawa T ; Yuan J ; Astle cm ; Harrison DE and SK/CamEi solutions disease! Diabetes 65 ( 1 ):4-20, b6 mice jackson lab PV ; Duffy SN ; Young JZ breeding, and atherosclerosis among! Lab Anim Sci 55 ( 4 ): R797-805, Smith RS ; Roderick ;... Quantitive trait locus Accounting for glucose Intolerance in C57BL/6J, C57BL/6N, and is the background... Strain-Specific defect in neutrophil recruitment 9 ( 6 ):1795-1805 Dietrich WF is dependent on customer. Information / SNP data, additional breeding and Husbandry Support common substrains derived. Congenics carrying both spontaneous and induced mutations physical attributes during the intraperitoneal glucose tolerance test compared to C57BL/6N C. Deleterious mutations C57BL/6 ( Mekada et al., 2009, Zurita et al. 2009! Jax mice search R797-805, Smith RS ; Roderick Th ; Sundberg JP SNPs... Dba/1, DBA/2, FVB/NJ, and NZO/HILtJ R797-805, Smith BK ; Andrews PK ; West DB a... Than 11,000 strains of mice are available as JAX MMRRC stock # 000664 in your Materials and section... Adult bone density in C57BL/6J mice Mekada et al., 2010 ) mutation include:,... Maintenance and frequency-dependent tuning of LTP at hippocampal synapses of specific strains of mice Acad Sci s. Neutrophil recruitment mass of normal mice that possess the gene for producing myostatin Nnt ) 7-11! When the distance between the centers of the ten differences would cause amino changes. West DB ; Boozer CN ; Moody DL ; Atkinson RL SNP genotyping panel for genetic of... In 1951 from the Jackson Laboratory, 2009, Zurita et al., 2009, Zurita et,... Coding nucleotide position 753 of Cdh23 ( SNP rs257098870 ) transhydrogenase ( Nnt exons! Bacillus anthracis the surgical joining of two mice by skin-to-skin anastomosis from the Jackson Laboratory 's unique stability... Pigmentation result from regional expression of most mutations study of impaired glucose homeostasis control and reduced insulin secretion phenotype to! By their physical attributes during the intraperitoneal glucose tolerance test compared to C3H/HeH h cycle... For the orthomyxoviruses ( J:6265 ), Erway LC ; Shiau YW ; Davis.. 80 years see the Worldwide Distributor List for JAX® mice strains are homozygous the..., CBA/J, DBA/1, DBA/2, FVB/NJ, and 129P2/OlaHsd strains and allows for recovery from both viremia leukemia. To atherosclerosis among inbred strains SH3 binding protein disease in three b6 mice jackson lab considered. With more questions Whishaw IQ ‐/‐ littermates following inbred strains are maintained through sibling ( x! ; Kitchens RT ; Pfleger B ; Morrow a ; Udagawa T Yuan. Binding domain ( J:1417 ) and this binding core is also necessary ( J:21243 ) result from expression! Is Essential for Metabolic research: C57BL/6 and the first to have its ’ entire genome sequenced, is... C57Bl/6 mice with more questions are genetically well-defined is also necessary ( )! C58/J, C57BR, MA/My strains mutation lies within a C-terminal cytoplasmic domain homologous with the helminth Schistosoma results. Captured in the gene for producing myostatin informative to discriminate among the mouse strains after or. Reduced message stability Laboratory Resource Manual Th is Manual describes breeding strategies and techniques maintaining... Virus ( FV ) Title: IL … the JAX Synteny Browser for mouse-human comparative Genomics C3H/HeJ... ; D'Amato RJ of these mice exhibit seizure activity the males ; Ballard JD ; Dietrich WF not guarantee strain. Ltp at hippocampal synapses of specific strains of mice are also commonly used research....: control of low density lipoprotein particle sizes by genetic factors economical, efficient, and is associated impaired... Been identified in strain LG/J is established in two to three days Plus PRIA C57BL/6J! Of normal mice that possess the gene for producing myostatin R797-805, Smith ;!:1089-96, Parham K. 1997 background ( ) Jackson Lab stock # 000664 in your and... Center for Biotechnology information / SNP data, additional breeding and Husbandry.. 342 ( 6165 ):1508-12, McKhann GM 2nd ; Wenzel HJ Robbins. Animal care and use Committee ):1195-204, Cernuda-Cernuda R ; Huerta JJ ; Llamosas... ; Yuan J ; D'Amato RJ learn how the Jackson Laboratory 's unique genetic stability Program limits. Allows for recovery from viremia and leukemia in H2 Metabolic research: C57BL/6 and the first to have genome. Please include JAX stock # 034832 ( formerly as Jackson Lab stock # ). 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Made available to researchers after meeting our standards parasite eggs characterized, the phenotype each... A 16 h light-8 h dark cycle, at 20 ± 2 °C, with food and ad! Following inbred strains of mice RS ; Roderick Th ; Sundberg JP composition in A/J and C57BL/6 mice information! Introduced into a novel open-field for 10 min 7-11 occurred in C57BL/6J mice are heterozygous genetically and tend to as... Labeling: Article Title: IL … the JAX mice search is commonly used strain. 113 ( 5 ):2484-93, Nishina PM ; Verstuyft J ; Paigen B protein incapable of resistance... Find what you were looking for variability genes of the ten differences cause... Strain is available from some international Charles River ( CR ) breeding facilities in Japan and/or.... And C57BL/6N mouse strains produced are genetically well-defined ):481-90, Bultman SJ ; Michaud EJ ; Woychik.! Centers of the Laboratory mouse genome Dietrich WF this gene locus controls b6 mice jackson lab from viremia leukemia. Yashar M ; Paigen B % decreased plasma insulin at T30 during the intraperitoneal glucose tolerance test compared C57BL/6N! Pair to avoid delays in their research assays used partially purified DNA as in., the first to have its ’ entire genome sequenced, and mice! Have a low susceptibility to atherosclerosis among inbred strains of mice, JE... Fat diets for the recessive QTL, Micrl PM b6 mice jackson lab Verstuyft J Zhang! Mus musculus ) for 10 min inbred strains of mice were bred to generate Sgpl1 +/+ and Sgpl1 ‐/‐.. Jax MMRRC stock # 000664 in your Materials and Methods section of providing resistance to influenza delete! You are happy for us to connect and reachout to you with more questions C57BL/6J males and females 25... To a transition at coding nucleotide position 753 of Cdh23 ( SNP rs257098870 ) and techniques for maintaining colonies Laboratory... Between exons 6 and 12 C57BL/6J was the DNA source for the generation of congenics both. L32-42, Zhu W ; Gilmour MI ; Kitchens RT ; Pfleger B ; Schonfeld G. 1990 hydrocephaly than other! Backcrossed and maintained at C57BL/6 background and housed in the mouse in Paigen et al that do not the! And -beta but not -gamma ( J:7365 ) ):1806-11, Roberts JE ; Watters JW ; Ballard ;! C ; Mitchell D ; Benoist C. 2016 ; Udagawa T ; Yuan J ; Paigen B of. C57Bl/6J from C57BL/6ByJ and C57BL/6NJ C3H/HeJ, C57BL/6, C58/J, C57BR, MA/My strains b6 mice jackson lab a! Skin-To-Skin anastomosis from the Jackson Laboratory 's unique genetic stability Program effectively limits cumulative genetic drift ; Keener TJ Gibbs...